
国家“杰出青年科学基金”获得者 滚球app官网下载,十大滚球体育app,表观遗传调控与干预全国重点实验室,研究组长
2000 - 2004? 信阳师范学院,获理学学士学位
2004 - 2010? 武汉大学,获理学博士学位
2010 - 2015? 美国加州大学圣地亚哥分校,博士后
2015 - 至今? ?滚球app官网下载,十大滚球体育app,研究员,博士生导师
2016 - 至今? ?中国科学院大学,岗位教授
2025年? 科学探索奖(生命科学)
2024年? 谈家桢生命科学创新奖
2022年? 药明康德生命化学研究奖
2021年? 中源协和生命医学创新突破奖
2021年? 中国科学院优秀导师奖
2021年? 中国科学院大学领雁银奖
2020年? 中国科学院优秀导师奖
2020年? 国家杰出青年科学基金
2015年? 国家优秀青年科学基金
曾获国家引才计划青年十大滚球体育app
本研究组围绕RNA结合蛋白和非编码RNA,主要关注RNA-蛋白质复合物在转录和表观遗传层面如何调控基因表达,以及如何在细胞分化、转分化和癌症发生等命运决定过程中发挥作用。主要研究内容包括:
一、非编码RNA的功能机制研究
人类基因组的广泛转录产生了海量的非编码RNA,它们虽然也携带遗传信息,但是往往不具备蛋白质编码潜能,其调控功能主要通过形成复杂的高级结构并与其它RNA分子相互作用而实现。我们重点关注增强子RNA(enhancer RNA,eRNA)、启动子RNA(promoter upstream antisense RNA,uaRNA)和长链非编码RNA(long noncoding RNA),期望通过利用各种RNA功能基因组学手段,系统研究这些非编码RNA的功能机制及其实现的结构基础。
二、RNA结合蛋白的转录调控机制
RNA结合蛋白可在转录和转录后水平调控基因表达。非编码RNA往往需要与RNA结合蛋白形成复合物以调控转录,因此研究RNA与蛋白质的相互作用位点和模式是探索非编码RNA功能机制的关键,也是我们课题组的重点关注方向。
三、RNA互作组学新技术开发
RNA在体内以高级结构形式存在,RNA结构的动态变化对于遗传信息的精确传递至关重要。目前,RNA的原位高级结构和作用靶标研究依然是领域内的瓶颈难题。我们将开发RNA空间互作组学新技术和计算新体系,以解决这些难题。此外,研究RNA结合蛋白的经典CLIP-seq方法需要大量的细胞,无法解决细胞的异质性和个别细胞数目稀缺的问题,因此亟待开发单细胞的功能基因组学研究方法。
1.?Youkun Bi#,?Xinlong Qiao#,?Zhaokui Cai,?Hailian Zhao,?Rong Ye,?Qun Liu,?Lin Gao,?Yingqi Liu,?Bo Liang,?Yixuan Liu,?Yaning Zhang,?Zhiguang Yang,?Yanyun Wu,?Huiwen Wang,?Wei Jia,?Changqing Zeng,?Ce Jia,?Hongjin Wu*,?Yuanchao Xue*,?Guangju Ji*. Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells. Cell Metab. 2025;37(2):527-541.e6.
2.?Rong Ye#,?Hailian Zhao#,?Xi Wang,?Yuanchao Xue*. Technological advancements in deciphering RNA-RNA interactions. Mol Cell. 2024;84(19):3722-3736.
3.?Liang Liang#,?Changchang Cao#,?Lei Ji#,?Zhaokui Cai#,?Di Wang,?Rong Ye,?Juan Chen,?Xiaohua Yu,?Jie Zhou,?Zhibo Bai,?Ruoyan Wang,?Xianguang Yang,?Ping Zhu,?Yuanchao Xue*. Complementary Alu sequences mediate enhancer-promoter selectivity. Nature. 2023;619(7971):868-875. (Highlight by Nature Reviews Genetics,2023,24: 588;Mol Cell,2023;83(18):3234-3235)
4.?Hailian Zhao#,?Zhaokui Cai#,?Jian Rao#,?Di Wu#,?Lei Ji,?Rong Ye,?Di Wang,?Juan Chen,?Changchang Cao,?Naijing Hu,?Ting Shu,?Ping Zhu,?Jianwei Wang*,?Xi Zhou*,?Yuanchao Xue*. SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis. Mol Cell. 2023: S1097-2765(23)00978-4. (Featured Article;Cover story)
5.?Rong Ye#,?Naijing Hu#,?Changchang Cao,?Ruibao Su,?Shihan Xu,?Chen Yang,?Xiangtian Zhou,?Yuanchao Xue*. Capture RIC-seq reveals positional rules of PTBP1-associated RNA loops in splicing regulation. Mol Cell. 2023;83(8):1311- 1327.e7. (Featured Article;Preview by Mol Cell,2023,83(8):1206-1207)
6.?Jing Guo#,?Hailian Zhao#,?Jue Zhang#,?Xiangjiang Lv,?Shen Zhang,?Ruibao Su,?Wei Zheng,?Jing Dai,?Fei Meng,?Fei Gong,?Guangxiu Lu,?Yuanchao Xue*,?Ge Lin*. Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition. Adv Sci. 2023;e2205500.
7.?Hui Li,?Hailian Zhao,?Chunhui Yang,?Ruibao Su,?Min Long,?Jinliang Liu,?Lanying Shi,?Yuanchao Xue*,?You-Qiang Su*. LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice. Adv Sci. 2023;10(18):e2300043.
8.?Yigan Zhang#,?Jinyue Zhang#,?Yuanchao Xue*. ADAR1: a mast regulator of aging and immunity. Signal Transduct Target Ther. 2023;8(1):7.
9.?Rong Ye#,?Naijing Hu#,?Yuanchao Xue*. CRIC-seq protocol for in situ profiling of proximal RNA-RNA contacts associated with RNA-binding proteins. STAR Protoc. 2023;4(3):102401.
10.?Jianzhong Su#*,?Jian Yuan#,?Liangde Xu#,?Shilai Xing#,?Mengru Sun#,?Yinghao Yao,?Yunlong Ma,?Fukun Chen,?Longda Jiang,?Kai Li,?Xiangyi Yu,?Zhengbo Xue,?Yaru Zhang,?Dandan Fan,?Ji Zhang,?Hui Liu,?Xinting Liu,?Guosi Zhang,?Hong Wang,?Meng Zhou,?Fan Lyu,?Gang An,?Xiaoguang Yu;?Myopia Associated Genetics and Intervention Consortium;?Yuanchao Xue*,?Jian Yang*,?Jia Qu*. Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population. Cell Rep. 2023;42(5):112510.
11.?Peng Wang#,?Qiushi Wang#,?Lianwan Chen#,?Zheng Cao#,?Hailian Zhao,?Ruibao Su,?Ning Wang,?Xiaojing Ma,?Jin Shan,?Xinyan Chen,?Qi Zhang,?Baochen Du,?Zhiheng Yuan,?Yanmei Zhao*,?Xiaorong Zhang*,?Xuejiang Guo*,?Yuanchao Xue*,?Long Miao*. RNA-binding protein complex AMG-1/SLRP-1 mediates germline development and spermatogenesis by maintaining mitochondrial homeostasis in Caenorhabditis elegans. Sci Bull. 2023;68(13):1399-1412.
12.?Yue Lv#,?Gang Lu#,?Yuling Cai#,?Ruibao Su#,?Liang Liang,?Xin Wang,?Wenyu Mu,?Xiuqing He,?Tao Huang,?Jinlong Ma,?Yueran Zhao,?Zi-Jiang Chen*,?Yuanchao Xue*,?Hongbin Liu*,?Wai-Yee Chan*. RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits. Protein Cell. 2022;14(1):51-63.
13.?Yuanchao Xue*. Architecture of RNA-RNA interactions. Curr Opin Genet Dev. 2022;72:138-144.
14.?Di Wang#,?Rong Ye#,?Zhaokui Cai,?Yuanchao Xue*. Emerging roles of RNA-RNA interactions in transcriptional regulation (Invited review). WIRES RNA. 2022;18:e1712.
15.?Changchang Cao#,?Zhaokui Cai#,?Xia Xiao#,?Jian Rao,?Juan Chen,?Naijing Hu,?Minnan Yang,?Xiaorui Xing,?Yongle Wang,?Manman Li,?Bing Zhou,?Xiangxi Wang,?Jianwei Wang*,?Yuanchao Xue*. The architecture of the SARS-CoV-2 RNA genome inside virion. Nat Commun. 2021;12(1):3917. (Best of BMB in 2021)
16.?Changchang Cao#,?Zhaokui Cai#,?Rong Ye,?Ruibao Su,?Naijing Hu,?Hailian Zhao,?Yuanchao Xue*. Global in situ profiling of RNA-RNA spatial interactions with RIC-seq. Nat Protoc. 2021;16(6):2916-2946.
17.?Ruibao Su#,?Li-Hua Fan#,?Changchang Cao#,?Lei Wang,?Zongchang Du,?Zhaokui Cai,?Ying-Chun Ouyang,?Yue Wang,?Qian Zhou,?Ligang Wu,?Nan Zhang,?Xiaoxiao Zhu,?Wen-Long Lei,?Hailian Zhao,?Yong Tian,?Shunmin He,?Catherine C L Wong*,?Qing-Yuan Sun*,?Yuanchao Xue*. Global profiling of RNA-binding protein target sites by LACE-seq. Nat Cell Biol. 2021;23(6):664-675.
18.?Zhaokui Cai#,?Changchang Cao#,?Lei Ji#,?Rong Ye,?Di Wang,?Cong Xia,?Sui Wang,?Zongchang Du,?Naijing Hu,?Xiaohua Yu,?Juan Chen,?Lei Wang,?Xianguang Yang,?Shunmin He,?Yuanchao Xue*. RIC-seq for global in situ profiling of RNA-RNA spatial interactions. Nature. 2020;582,432-437. (Highlight by Nature Methods,2020,17,760;Recommended in Faculty Opinions)
19.?Juan Chen#,?Zhaokui Cai#,?Meizhu Bai#,?Xiaohua Yu#,?Chao Zhang#,?Changchang Cao,?Xihao Hu,?Lei Wang,?Ruibao Su,?Di Wang,?Lei Wang,?Yingpeng Yao,?Rong Ye,?Baidong Hou,?Yang Yu,?Shuyang Yu,?Jinsong Li,?Yuanchao Xue*. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. Cell Res. 2018;28: 981-995. (Cover story;highlight by Cell Res,2018 (10):963-964)
20.?Jinyang Zhang#,?Lingling Hou#,?Zhenqiang Zuo#,?Peifeng Ji,?Xiaorong Zhang,?Yuanchao Xue,?Fangqing Zhao*. Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long. Nat Biotechnol. 2021;39(7):836-845.
21.?Yuanchao Xue,?Runsheng Chen*,?Lianghu Qu*,?Xiaofeng Cao*. Noncoding RNA: from dark matter to bright star. Science China Life sciences. 2020;63,463-468.
22.?Rong Ye,?Changchang Cao,?Yuanchao Xue*. Enhancer RNA: biogenesis,function,and regulation. Essays Biochem. 2020;64(6):883-894.
23.?Yuanchao Xue#,*,?Hao Qian#,?Jing Hu,?Bing Zhou,?Yu Zhou,?Xihao Hu,?Aziz Karakhanyan,?Zhiping Pang,?Xiang-Dong Fu*. Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. Nat Neurosci. 2016;19(6):807-15.
24.?Juan Chen#,?Yuanchao Xue*. Emerging roles of non-coding RNAs in epigenetic regulation. Sci China Life Sci. 2016;59(3):227-35.
25.?Yuanchao Xue,?Kunfu Ouyang,?Jie Huang,?Yu Zhou,?Hong Ouyang,?Hairi Li,?Gang Wang,?Qijia Wu,?Chaoliang Wei,?Yanzhen Bi,?Li Jiang,?Zhiqiang Cai,?Hui Sun,?Kang Zhang,?Yi Zhang,?Ju Chen,?Xiang-Dong Fu*. Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell. 2013;152(1-2):82-96. (Highlight by Nature,2013,493: 275;Science,2013,339: 374;Nature Reviews Neuroscience,2013,14,155)
26.?Yuanchao Xue#,?Yu Zhou#,?Tongbin Wu,?Tuo Zhu,?Xiong Ji,?Young-SooKwon,?Chao Zhang,?Gene Yeo,?Douglas L. Black,?Hui Sun,?Xiang-Dong Fu*,?Yi Zhang*. Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping. Mol Cell. 2009;36(6):996-1006.(Cover story;Preview by Mol Cell,2009;36(6):918-9)
(资料来源:薛愿超研究员,2025-09-26)